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Host-induced aneuploidy and phenotypic diversification in the Sudden Oak Death pathogen Phytophthora ramorum

TitleHost-induced aneuploidy and phenotypic diversification in the Sudden Oak Death pathogen Phytophthora ramorum
Publication TypeJournal Article
2016
AuthorsKasuga, T, Bui, M, Bernhardt, E, Swiecki, T, Aram, K, Cano, LM, Webber, J, Brasier, C, Press, C, Grünwald, NJ, Rizzo, DM, Garbelotto, M
JournalBMC Genomics
Volume17
Pagination1–17
ISSN1471-2164

Aneuploidy can result in significant phenotypic changes, which can sometimes be selectively advantageous. For example, aneuploidy confers resistance to antifungal drugs in human pathogenic fungi. Aneuploidy has also been observed in invasive fungal and oomycete plant pathogens in the field. Environments conducive to the generation of aneuploids, the underlying genetic mechanisms, and the contribution of aneuploidy to invasiveness are underexplored. We studied phenotypic diversification and associated genome changes in Phytophthora ramorum, a highly destructive oomycete pathogen with a wide host-range that causes Sudden Oak Death in western North America and Sudden Larch Death in the UK. Introduced populations of the pathogen are exclusively clonal. In California, oak (Quercus spp.) isolates obtained from trunk cankers frequently exhibit host-dependent, atypical phenotypes called non-wild type (nwt), apparently without any host-associated population differentiation. Based on a large survey of genotypes from different hosts, we previously hypothesized that the environment in oak cankers may be responsible for the observed phenotypic diversification in P. ramorum.

http://dx.doi.org/10.1186/s12864-016-2717-z
10.1186/s12864-016-2717-z
Citation KeyKasuga2016